Alterations in neurotrophins and neurotrophin receptors in Alzheimer's disease

Authors
Hock, C Heese, K Olivieri, G Hulette, C Rosenberg, C Nitsch, RM Otten, U
Citation
C. Hock et al., Alterations in neurotrophins and neurotrophin receptors in Alzheimer's disease, J NEUR TR-S, (59), 2000, pp. 171-174
Citations number
14
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT
ISSN journal
03036995 → ACNP
Issue
59
Year of publication
2000
Pages
171 - 174
Database
ISI
SICI code
0303-6995(2000):59<171:AINANR>2.0.ZU;2-O
Abstract
We demonstrated that nerve growth factor (NGF) levels were increased in hip pocampus and cortical areas, as well as in cerebrospinal fluid (CSF) of pat ients with Alzheimer's disease (AD). Such increases may, at least in part, be due to a decreased expression of the NGF high affinity receptor trkA. Me asurement of CSF levels of NGF may add to the repertoire of potential bioch emical diagnostic markers in living AD patients.