Cerebrolysin (R) reduces microglial activation in vivo and in vitro: a potential mechanism of neuroprotection

Neurotrophins, such as NGF, BDNF and NT-3 play a regulatory role on the fun ction of microglial cells in vivo and in vitro, and the identification of n ew compounds with neurotrophic properties is becoming a new strategy for th e prevention and/or treatment of neurodegenerative disorders. In this study we describe the use of two different models to demonstrate the ability of Cerebrolysin(R) to reduce microglial activation. The results of these in vi tro and in vivo studies indicate that Cerebrolysin(R) might exert a neuroim munotrophic activity reducing the extent of inflammation and accelerated ne uronal death under pathological conditions such as those observed in neurod egenerative diseases.