F. Goto et al., Expansion of afferent vestibular signals after the section of one of the vestibular nerve branches, J NEUROPHYS, 84(1), 2000, pp. 581-584
The anterior branch of N. VIII was sectioned in adult frogs. Two months lat
er the brain was isolated to record in vitro responses in the vestibular nu
clei and from the abducens nerves following electric stimulation of the ant
erior branch of N. VIII or of the posterior canal nerve. Extra- and intrace
llularly recorded responses from the intact and operated side were compared
with responses from controls. Major changes were detected on the operated
side: the amplitudes of posterior canal nerve evoked field potentials were
enlarged, the number of vestibular neurons with a monosynaptic input from t
he posterior canal nerve had increased, and posterior canal nerve stimulati
on recruited stronger abducens nerve responses on the intact side than vice
versa. Changes in the convergence pattern of vestibular nerve afferent inp
uts on the operated side strongly suggest the expansion of posterior canal-
related afferent inputs onto part of those vestibular neurons that were dep
rived of their afferent vestibular input. As a mechanism we suggest reactiv
e synaptogenesis between intact posterior canal afferent fibers and vestibu
larly deprived second-order vestibular neurons.