Microwave-mediated palladium-catalyzed asymmetric allylic alkylation; an example of highly selective fast chemistry

Authors
Kaiser, NFK Bremberg, U Larhed, M Moberg, C Hallberg, A
Citation
Nfk. Kaiser et al., Microwave-mediated palladium-catalyzed asymmetric allylic alkylation; an example of highly selective fast chemistry, J ORGMET CH, 603(1), 2000, pp. 2-5
Citations number
24
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANOMETALLIC CHEMISTRY
ISSN journal
0022328X → ACNP
Volume
603
Issue
1
Year of publication
2000
Pages
2 - 5
Database
ISI
SICI code
0022-328X(20000522)603:1<2:MPAAAA>2.0.ZU;2-V
Abstract
Highly enantioselective palladium-catalyzed microwave-mediated fast chemist ry has been performed on dimethyl malonate alkylation of(rac)-1,3-diphenyla llyl-1-acetate (1). Utilizing the recently developed palladium-phosphineoxa zoline catalytic system, with general stability at elevated temperatures (l ess than or equal to 145 degrees C), quantitative yields of greater than or equal to 97% and ee values of up to >99% were obtained after very short ir radiation times (15-300 s, TOF up to 7000 h(-1)). (C) 2000 Elsevier Science S.A. All rights reserved.