Asymmetric synthesis of fluorinated beta-hydroxy esters via ruthenium-mediated hydrogenation

Authors
Blanc, D Ratovelomanana-Vidal, V Gillet, JP Genet, JP
Citation
D. Blanc et al., Asymmetric synthesis of fluorinated beta-hydroxy esters via ruthenium-mediated hydrogenation, J ORGMET CH, 603(1), 2000, pp. 128-130
Citations number
28
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANOMETALLIC CHEMISTRY
ISSN journal
0022328X → ACNP
Volume
603
Issue
1
Year of publication
2000
Pages
128 - 130
Database
ISI
SICI code
0022-328X(20000522)603:1<128:ASOFBE>2.0.ZU;2-G
Abstract
The homogeneous asymmetric hydrogenation reactions of fluorinated P-keto es ters using ruthenium(II) complexes bearing atropoisomeric diphosphines such as BINAP and MeO-BIPHEP have yielded the corresponding P-hydroxy esters in quantitative yield with ee that ranged between 42 and > 95%. (C) 2000 Publ ished by Elsevier Science S.A. All rights reserved.