ESTIMATING MEAN PULMONARY WEDGE PRESSURE IN PATIENTS WITH CHRONIC ATRIAL-FIBRILLATION FROM TRANSTHORACIC DOPPLER INDEXES OF MITRAL AND PULMONARY VENOUS FLOW VELOCITY
F. Chirillo et al., ESTIMATING MEAN PULMONARY WEDGE PRESSURE IN PATIENTS WITH CHRONIC ATRIAL-FIBRILLATION FROM TRANSTHORACIC DOPPLER INDEXES OF MITRAL AND PULMONARY VENOUS FLOW VELOCITY, Journal of the American College of Cardiology, 30(1), 1997, pp. 19-26
Objectives. We sought to obtain a noninvasive estimation of mean pulmo
nary wedge pressure (MPWP) in patients with chronic atrial fibrillatio
n (AF). Background. It has previously been demonstrated that MPWP fan
be reliably estimated from Doppler indexes of mitral and pulmonary ven
ous how (PVF) in patients with sinus rhythm. Doppler estimation of MPW
P has not been validated in patients with AF. Methods. MPWP was correl
ated with variables of mitral and pulmonary venous flow velocity as as
sessed by Doppler transthoracic echocardiography in 35 consecutive pat
ients. The derived algorithm aas prospectively tested in 23 additional
patients. Results. In all patients the mitral flow pattern showed onl
y a diastolic forward component. A significant but relatively weak cor
relation (r = -0.50) was observed between MPWP and mitral deceleration
time. In 12 (34%) of 35 patients, the pulmonary vein how tracing demo
nstrated only a diastolic forward component; a diastolic and late syst
olic forward flow was noted in the remaining 23 patients (66%). A stro
ng negative correlation was observed between MPWP and the normalized d
uration of the diastolic flow (r = -0.80) and its initial deceleration
slope time r = -0.91). Deceleration time >220 ms predicted MPWP less
than or equal to 12 mm Hg with 100% sensitivity and 100% specificity.
When estimating MPWP by using the equation MPWP = -94.261 PVF decelera
tion time - 9.831 Interval QRS to onset of diastolic PVP - 16.337 Dura
tion of PVF + 44261, the measured and predicted MPWP closely agreed wi
th a mean difference of -0.85 mm Hg. The 95% confidence Limits were 4.
8 and -6.1 mm Hg. Conclusions. In patients with chronic AF, MPWP can b
e estimated from transthoracic Doppler study of PVF velocity signals.
(C) 1997 by the American College of Cardiology.