Surface modification of activated polymeric matrices by dendritic attachments

Aware of the growing interest in materials that exhibit specific physiochem ical properties and potential applications, we focused our work on modifyin g commercial agarose with polyfunctional dendrons capable of molecular reco gnition through hydrogen bonding. 2,6-Di(acylamino)pyridine moieties within the internal superstructure of dendritic macromolecules have been reported to be capable of forming H-bonded complexes with imide groups, such as bar bituric acid and its derivatives. We report the synthesis of new dendrons p ossessing multiple 2,6-di(acylamino)pyridinyl sites, each capable of molecu lar recognition, and the development of new polymeric supports of an activa ted agarose matrix by surface modification. From comparative studies of the beads modified by different dendrons, we found improved results in those d endritic supports possessing 2,6-di(acylamino)pyridinyl moieties, except wh en their juxtaposition between the groups promoted inner H bonds. (C) 2000 John Wiley & Sons, Inc.