Total synthesis of antillatoxin, an ichthyotoxic cyclic lipopeptide from marine cyanobacterium Lyngbya majuscula

Antillatoxin is an ichthyotoxic cyclic lipopeptide isolated by Gerwick and co-workers from the marine cyanobacterium Lyngbya majuscula collected in Cu racao. Although we have finished the stereoselective total synthesis of ant illatoxin having the proposed structure with (4S, 5R)-configuration, we hav e found that the synthetic sample was not identical with the natural one an d the proposed structure should be revised. Further our synthetic efforts h ave culminated in the first total synthesis of antillatoxin in its natural form, proving that the natural one has (4R, 5R)-configuration. In this acco unt, our total synthesis and synthetic studies by other groups will be disc ussed.