Yh. Chien et al., Nephrotic syndrome in a bone marrow transplant recipient without chronic graft-versus-host disease, J FORMOS ME, 99(6), 2000, pp. 503-506
A 5-year-old girl developed severe proteinuria and microscopic hematuria 17
months after allogeneic bone marrow transplantation (BMT) for chronic myel
oid leukemia. These nephrotic symptoms occurred during cyclosporin tapering
, in the absence of other signs of chronic graft-versus-host disease (GVHD)
. A renal biopsy revealed focal segmental glomerulosclerosis. After methylp
rednisolone therapy, the proteinuria gradually decreased. The altered or di
sordered immune regulation that occurred after BMT may have resulted in the
development of nephrotic syndrome.