Lipase-catalyzed resolution of ibuprofen

Authors
Henke, E Schuster, S Yang, H Bornscheuer, UT
Citation
E. Henke et al., Lipase-catalyzed resolution of ibuprofen, MONATS CHEM, 131(6), 2000, pp. 633-638
Citations number
12
Categorie Soggetti
Chemistry
Journal title
MONATSHEFTE FUR CHEMIE
ISSN journal
00269247 → ACNP
Volume
131
Issue
6
Year of publication
2000
Pages
633 - 638
Database
ISI
SICI code
0026-9247(200006)131:6<633:LROI>2.0.ZU;2-A
Abstract
The resolution of ibuprofen by transesterification of its corresponding vin ylester using lipase B from Candida antarctica is described. Compared to tr ansesterification or hydrolysis of the ibuprofen ethyl ester (E < 2, 28-48 h), the reaction with vinylesters occurred significantly faster (1.5-5 h) a nd with considerably higher enantioselectivity (E = 8-39).