H. Hori et al., Manganese superoxide dismutase gene polymorphism and schizophrenia: Relation to tardive dyskinesia, NEUROPSYCH, 23(2), 2000, pp. 170-177
There has been increasing evidence that deranged superoxide dismutase (SOD)
activities might be a risk factor for schizophrenia and/or tardive dyskine
sia (TD). In the present study, we investiogated the genetic association be
tween a functional polymorphism (Ala-9Val) in the human manganese (Mn) SOD
gene and schizophrenia or TD (192 schizophrenics : 39 with TD and 153 witho
ut TD; 141 controls). No significant differences in the allelic or genotypi
c distribution between schizophrenics and controls were observed. However,
we did find a significant difference in genotypic distribution between schi
zophrenics with and those without TD (p = .03). Moreover, decreased -9Ala (
mutant) allele was found among patients with TD (p = .02; odds ratio = 0.29
; 95% confidence interval = 0.10-0.83). In conjunction with previous findin
gs of increased free radicals and decreased SOD activities in TD subjects,
these results suggest that the -9Ala (high activity) MnSOD allele may play
a role in protecting against susceptibility to TD in schizophrenics. (C) 20
00 American College of Neuropsychopharmacology. Published by Elsevier Scien
ce Inc. All rights reserved.