PLATELET 5-HT LEVELS AND HYPOTHALAMIC-PITUITARY-ADRENAL AXIS ACTIVITYIN SCHIZOPHRENIC-PATIENTS WITH POSITIVE AND NEGATIVE SYMPTOMS

Authors
PIVAC N MUCKSELER D JAKOVLJEVIC M
Citation
N. Pivac et al., PLATELET 5-HT LEVELS AND HYPOTHALAMIC-PITUITARY-ADRENAL AXIS ACTIVITYIN SCHIZOPHRENIC-PATIENTS WITH POSITIVE AND NEGATIVE SYMPTOMS, Neuropsychobiology, 36(1), 1997, pp. 19-21
Citations number
21
Categorie Soggetti
Psychiatry,Neurosciences
Journal title
Neuropsychobiology → ACNP
ISSN journal
0302282X
Volume
36
Issue
1
Year of publication
1997
Pages
19 - 21
Database
ISI
SICI code
0302-282X(1997)36:1<19:P5LAHA>2.0.ZU;2-7
Abstract
Hypothalamic-pituitary-adrenal (HPA) axis activity and platelet 5-HT c oncentrations were determined before dexamethasone suppression test (D ST) in 80 male schizophrenic patients with predominantly positive or n egative symptoms. Significant differences in platelet 5-HT and no diff erences in baseline plasma cortisol concentrations among schizophrenic suppressors and nonsuppressors were found. A similar rate of nonsuppr ession (56% positive and 53% negative schizophrenic patients) was dete cted. Platelet 5-HT, but not plasma cortisol concentrations, could be used to differentiate positive and negative symptoms of schizophrenia.