F. Nava et al., Lipopolysaccharide increases arginine-vasopressin release from rat suprachiasmatic nucleus slice cultures, NEUROSCI L, 288(3), 2000, pp. 228-230
The aim of this study was to determine whether Escherichia coli lipopolysac
charide at the doses of 25, 50 and 100 mu M influences arginine-vasopressin
(AVP) secretion in young rat suprachiasmatic nucleus (SCN) neurons. Lipopo
lysaccharide administered in the medium for 3 h increased significantly the
arginine-vasopressin release lasting up to 6 h after treatment. These resu
lts provide the first evidence that lipopolysaccharide influences AVP secre
tion in SCN neurons. Moreover, these findings may explain some central effe
cts observed in vivo after lipopolysaccharide administration. (C) 2000 Else
vier Science Ireland Ltd. All rights reserved.