Tympanic membrane perforation repair using AlloDerm

BACKGROUND: Some patients lack quality autologous tissue for tympanic membr ane (TM) grafting. AlloDerm (LifeCell Corp, The Woodlands, TX) is a preserv ed allograft that has been effective in nonotologic applications. OBJECTIVE: The goal of this study was to investigate AlloDerm In the repair of chronic TM perforations, METHODS: Ten adult chinchillas underwent a controlled, 2-stage procedure fo r creation and repair of bilateral TM perforations, Myringoplasties were pe rformed. The control side (left) was repaired with autologous fascia; AlloD erm was used in all right ears, Grafts were assessed at 3 to 8 weeks. RESULTS: Complete TM perforation closure was noted in 9 of 10 (90%) control ears and 8 of 10 (80%) AlloDerm-treated ears, Fascia and AlloDerm integrat ed consistently with host tissues. No variables demonstrated statistical si gnificance. CONCLUSIONS: AlloDerm appeared to be an ideal substitute for grafting of th e TM. It was equally effective as fascla. Clinical trials in human beings a ppear warranted. Potential health care savings are discussed.