One rare case of POEMS syndrome is presented. In a 39-year-old male patient
a progressive numbness in hands and feet developed within 5 years. Admissi
on with increasing dyspoea and lower leg edema. In swollen inguinal lymph n
odes a lymphadenopathia with angiofollicular hyperplasia and vascular-plasm
acelluluar proliferation was diagnosed and classified as Castleman-like his
tologic features. In os ilium an osteosclerotic plasmocytoma with restricti
on of kappa light chains was found. Potential pathomechanism of POEMS syndr
ome are discussed.