Involvment of CDC25 phosphatases in growth control.

Progression in cell cycle is controlled by CDKs (cyclin dependent kinases) and their cyclins regulatory subunits. In mammalian cells, three dual speci ficity phosphatases called CDC25 activate CDKs/cyclin complexes. The activi ty of CDC25 is regulated by phosphorylation and dephosphorylation events. C DC25 phosphatases also participate in cell cycle checkpoints activated in r esponse to DNA damage. Two members of this family, CDC25 A and CDC25 B, hav e oncogenic properties, and their overexpression has been detected in vario us types of tumors. (C) 2000 Editions scientifiques et medicales Elsevier S AS.