Carcinosarcoma of the parotid gland: Cytological, clinicopathological and immunohistochemical study of a case

Manifesting a putative origin from a pleomorphic adenoma, carcinosarcoma of the salivary gland is a heterologous neoplasm in which a sarcomatous and a carcinomatous component coexist. We present a parotid gland carcinosarcoma in a 77-year-old man with peculia r morphological findings. Fine-needle aspiration cytology allowed a preoper ative diagnosis of poorly differentiated carcinoma. At histologic examinati on the turner showed biphasic differentiation with an epithelial component made up of well-differentiated keratinizing squamous carcinoma and ductal-t ype adenocarcinoma, and a mesenchymal component, revealing focal areas of o steosarcoma and myoepithelial malignant proliferation. Carcinosarcoma is a very rare malignant neoplasm, accounting for 0.16% of m alignant salivary gland tumors: only 60 cases have been reported, some of w hich arose "de novo", i.e., without clinico-pathologic evidence of a pre- o r co-existing pleomorphic adenoma.