Molecular biology of autosomal dominant polycystic kidney disease

Among the prevalent human genetic disorders, human autosomal dominant polyc ystic kidney disease is certainly one of the most challenging, both from a clinical and a fundamental perspective. In the recent years, important Prog ress opened novel research avenues to elucidate the genetic basis, the cell ular Path ophysiologic mechanisms and the molecular function of genes and p roteins involved in autosomal dominant polycystic kidney disease.