A NOVEL CONCEPT CONCERNING PARTICIPATION OF CEREBRAL HYPOXIA IN PATHOGENESIS OF NEUROSES

The data are presented concerning the state of vascular brain system d uring experimental neurosis in Vistar rats, the intricate cerebral hem odynamical disturbances, shifts in activity of the crucial enzymes of the mitochondrial respiratory chain, and activation of the lipid perox idation processes. The positive results on treatment of the experiment al and clinical neuroses with antioxidants which have antihypoxic prop erties are presented. Results on increase of resistance. to stress in rats under the influence of negatively charged air ions with expressed antihypoxic are discussed. The general outline is given of the molecu lar neurochemical processes which accompany the development of neuroti c diseases as well as of reversal of these processes due to the antiox idant therapy. The concept concerning the cerebral hypoxia in neuroses is based on the obtained evidence. This concept opens the principally novel pathogenetical approaches to treatment and prevention of these diseases.