Preparation and characterisation of composites based on biodegradable polymers for "in vivo" application

Citation
L. Calandrelli et al., Preparation and characterisation of composites based on biodegradable polymers for "in vivo" application, POLYMER, 41(22), 2000, pp. 8027-8033
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
POLYMER
ISSN journal
00323861 → ACNP
Volume
41
Issue
22
Year of publication
2000
Pages
8027 - 8033
Database
ISI
SICI code
0032-3861(200010)41:22<8027:PACOCB>2.0.ZU;2-W
Abstract
Poly(L-lactic) acid (PLLA), polycaprolactone (PCL), three different copolym ers based on poly(L-lactic) acid and polyglycolic acid (PLLA-co-PGA), and t heir composites with hydroxyapatite obtained from bovine bone (ossein), wer e tested in order to have information on the thermal, morphological, mechan ical and biochemical properties in view of their use as biocompatible/biode gradable materials. Ossein, which is essentially a biological hydroxyapatit e, was found to improve the modulus and increase the hydrophilicity of the polymeric substrate. In addition, the size of the ossein particles was foun d to be critical for the improvement of mechanical properties. Finally, pre liminary results on the in vitro biocompatibility of selected blends carrie d out by using primary cultures of human osteoblasts showed that the presen ce of hydroxyapatite stimulates a more positive cellular response. (C) 2000 Elsevier Science Ltd. All rights reserved.