Study of the hydrolytic degradation of polydioxanone PPDX

The hydrolytic degradation of bioabsorbable polydioxanone (PPDX) was studie d in a phosphate buffer solution, pH = 7.4, 37 degrees C. The degradation w as evaluated by analyzing the changes in the elastic modulus and morphologi cal changes. After 10 weeks, the weight loss, pH and molecular weight chang es suggested diffusion of low molecular weight chain segments into the reac tion medium as a consequence of the breaking of ester bonds in the material . The crystallinity (X-c) increased with hydrolysis time, indicating the fi rst step of the degradation process. Modulus was found to decrease, indicat ing that chain scission proceeded in two steps: the first occurring in the amorphous regions of microfibrils and intermicrofibrillar space; the second in the crystalline regions, resulting in a lower stress value for the chai n segments when submitted to external forces. Surface morphological changes suggest a heterogeneous degradation mechanism by layers. (C) 2000 Elsevier Science Ltd. All rights reserved.