Synthesis of RGD containing peptides and their vasodilation effect

APLRV, SLRR, RGDS, and RGDF were synthesized by use of the solution method via the corresponding protective intermediates. After fragment condensation and deprotection, APLRVRGDS, APLRVRGDF, SLRRRGDS, and SLRRRGDF were obtain ed. The effect of these RGD containing peptides on rat aortic strips pretre ated with noradrenaline (NE) were observed. The relaxing extents of contrac ted strips for them at three doses (10(-5) mol/L, 10(-6) mol/L and 10(-7) m ol/L) indicated that, in a few cases, this kind of combination of these fra gments may enhance the desirable activity.