Citation
Zl. Wei et al., Chemoenzymatic synthesis of Ro 25-8210 and Ro 25-6630, SCI CHINA B, 43(3), 2000, pp. 331-336
Citations number
7
Categorie Soggetti
Chemistry
Journal title
SCIENCE IN CHINA SERIES B-CHEMISTRY
ISSN journal
1001652X
→ ACNP
Volume
43
Issue
3
Year of publication
2000
Pages
331 - 336
Database
ISI
SICI code
1001-652X(200006)43:3<331:CSOR2A>2.0.ZU;2-1
Abstract
Here we report the chemoenzymatic synthesis of Ro 25-8210 (1) and Ro 25-663
0 (2) by using microbial reduction of a-chloromethyl ketone 4 mediated with
baker's yeast and Geotrichum sp. to afford the optically active (R) and (S
)-alpha-chlorohydrin 8 respectively as the key step.