M. Fujii et al., Facile synthesis of 3,4-dihydroxyprolines as an application of the L-threonine aldolase-catalyzed aldol reaction, SYNLETT, (7), 2000, pp. 1046-1048
A new facile synthesis of 3,4-dihydroxyprolines was attained by taking adva
ntage of the L-threonine aldolase, which catalyzes the aldol condensation r
eaction of aldehydes with glycine affording beta-hydroxy-alpha-L-amino acid
s.