Efficient synthesis of optically active 2-azido-1-arylethanols via oxazaborolidine - Catalysed asymmetric borane reduction

Authors
Yadav, JS Reddy, PT Hashim, SR
Citation
Js. Yadav et al., Efficient synthesis of optically active 2-azido-1-arylethanols via oxazaborolidine - Catalysed asymmetric borane reduction, SYNLETT, (7), 2000, pp. 1049-1051
Citations number
24
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
7
Year of publication
2000
Pages
1049 - 1051
Database
ISI
SICI code
0936-5214(200007):7<1049:ESOOA2>2.0.ZU;2-6
Abstract
A simple, efficient, stereo- and regio-selective method for the synthesis o f optically active 2-azido-1-phenylethanols by asymmetric reduction of 2-az idoacetophenones with in situ generated, oxazaborolidine-borane complexes i n THF, is described. This new method appears to be an alternative to the cl assical methods previously reported.