Efficient synthesis of resin-bound alpha-TMSdiazoketones and their use in solid-phase organic synthesis

alpha-TMSdiazokotones on a solid support could be simply and efficiently pr epared by reaction of the corresponding resin-bound acid chlorides with exc ess TMSdiazomethane, without any bases. These alpha-TMSdiazoketones were us ed via carbenes or carbenoids for a variety of solid-phase reactions. These useful solid-phase reactions allow efficient construction of diverse compo und libraries by use of combinatorial chemistry, due to the high reactivity and wide applications of the carbenes or carbenoids. (C) 2000 Elsevier Sci ence Ltd. All rights reserved.