Yz. Sun et al., Synthesis of a new diaminodithiol bifunctional chelator for radiolabeling biomolecules with indium(III), TETRAHEDRON, 56(29), 2000, pp. 5093-5103
The synthesis of a new bifunctional ligand 1-(p-carboxybenzyl)-N,N'-bis-[1,
1-dimethyl-1-(p-methoxybenzylthio)ethyl]-ethylenediamine-N,N'-diacetic acid
, di-t-butyl ester (1, nbi6ss) is described. It consists of a carboxybenzyl
group substituted on a carbon atom of the ethylenediamine moiety of a hexa
dentate ligand, which has been found to have a very high affinity for In(II
I). The gem-dimethylthiol groups and the carboxylic acid groups of the liga
nd were protected by groups that can be removed under mild conditions after
conjugation to a peptide or protein. (C) 2000 Elsevier Science Ltd. All ri
ghts reserved.