Synthesis of a new diaminodithiol bifunctional chelator for radiolabeling biomolecules with indium(III)

Citation
Yz. Sun et al., Synthesis of a new diaminodithiol bifunctional chelator for radiolabeling biomolecules with indium(III), TETRAHEDRON, 56(29), 2000, pp. 5093-5103
Citations number
26
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
29
Year of publication
2000
Pages
5093 - 5103
Database
ISI
SICI code
0040-4020(20000714)56:29<5093:SOANDB>2.0.ZU;2-I
Abstract
The synthesis of a new bifunctional ligand 1-(p-carboxybenzyl)-N,N'-bis-[1, 1-dimethyl-1-(p-methoxybenzylthio)ethyl]-ethylenediamine-N,N'-diacetic acid , di-t-butyl ester (1, nbi6ss) is described. It consists of a carboxybenzyl group substituted on a carbon atom of the ethylenediamine moiety of a hexa dentate ligand, which has been found to have a very high affinity for In(II I). The gem-dimethylthiol groups and the carboxylic acid groups of the liga nd were protected by groups that can be removed under mild conditions after conjugation to a peptide or protein. (C) 2000 Elsevier Science Ltd. All ri ghts reserved.