A base-catalyzed domino-isomerization-hydroamination reaction - A new synthetic route to amphetamines

Authors
Hartung, CG Breindl, C Tillack, A Beller, M
Citation
Cg. Hartung et al., A base-catalyzed domino-isomerization-hydroamination reaction - A new synthetic route to amphetamines, TETRAHEDRON, 56(29), 2000, pp. 5157-5162
Citations number
82
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
29
Year of publication
2000
Pages
5157 - 5162
Database
ISI
SICI code
0040-4020(20000714)56:29<5157:ABDR-A>2.0.ZU;2-A
Abstract
An efficient synthesis of pharmaceutically interesting amphetamines by a ba se-catalyzed domino-isomerization-hydroamination reaction is presented. Sta rting from allylbenzene and various primary or secondary amines, the basic structural pattern of amphetamines is synthesized directly in yields of up to 91% in the presence of catalytic amounts of n-butyllithium. (C) 2000 Els evier Science Ltd. All rights reserved.