Highly efficient synthesis of steroidal hydroxamic acid derivatives via homogeneous catalytic carbonylation reaction

Authors
Szarka, Z Skoda-Foldes, R Kollar, L Berente, Z Horvath, J Tuba, Z
Citation
Z. Szarka et al., Highly efficient synthesis of steroidal hydroxamic acid derivatives via homogeneous catalytic carbonylation reaction, TETRAHEDRON, 56(29), 2000, pp. 5253-5257
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
29
Year of publication
2000
Pages
5253 - 5257
Database
ISI
SICI code
0040-4020(20000714)56:29<5253:HESOSH>2.0.ZU;2-F
Abstract
Steroidal hydroxamic acid derivatives were synthesized in moderate to high yields by palladium-catalyzed carbonylation reactions of the corresponding iodo-alkenyl compounds or enol triflates in the presence of substituted hyd roxylamines under mild reaction conditions. The effect of reaction paramete rs on the regioselectivity of carbonylation of N-substituted hydroxylamines is investigated in detail. (C) 2000 Elsevier Science Ltd. All rights reser ved.