Synthesis of enantiomerically pure bicyclic condensed delta-lactones via microbial reduction and enzymic resolution strategies

Authors
Fogal, E Forzato, C Nitti, P Pitacco, G Valentin, E
Citation
E. Fogal et al., Synthesis of enantiomerically pure bicyclic condensed delta-lactones via microbial reduction and enzymic resolution strategies, TETRAHEDR-A, 11(12), 2000, pp. 2599-2614
Citations number
70
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
12
Year of publication
2000
Pages
2599 - 2614
Database
ISI
SICI code
0957-4166(20000630)11:12<2599:SOEPBC>2.0.ZU;2-Q
Abstract
The formation of enantiopure delta-lactones condensed with alicyclic rings has been achieved either by reduction with baker's yeast of the correspondi ng delta-keto esters and delta-keto acids or by enzymic resolution of the f ormer compounds. The absolute configurations of the lactones were determine d by means of CD spectroscopy, using the correlation method. (C) 2000 Elsev ier Science Ltd. All rights reserved.