In vitro activity of enrofloxacin and other fluoroquinolones in companion and livestock animals

This in vitro study was aimed to compare the intrinsic activity of modern 3 (rd) generation fluoroquinolones (enrofloxacin, difloxacin, marbofloxacin, and orbifloxacin) in current isolates of companion and livestock animals. O ur results prove the good in vitro performance of the whole class, but clea rly underline the great superiority of enrofloxacin regarding MICs, MBCs an d the killing in all bacterial species investigated. In times of a constant ly growing awareness of a rational use of antimicrobials, this investigatio n was restricted to bacterial species claimed by the marketing authorisatio n of fluoroquinolones. The activities were determined quantitatively (MIC, MBC, time-kill-studies). Those data allow-in contrast to qualitative data ( susceptible, intermediate and resistant)-a state of the art judgement of di fferent antimicrobials.