Effect of thiamine hydrochloride on lead induced lipid peroxidation in ratliver and kidney

Thiamine hydrochloride was studied on lead-induced endogenous lipid peroxid ation in rat hepatic and renal tissues following po doses of 2.73 mg lead/k g bw for 6 w. Simultaneous use of 25 mg thiamine hydrochloride/kg bw po red uced lead accumulation in liver and kidneys. There were significant decreas es in endogenous lipid peroxide in liver and kidney from thiamine hydrochlo ride-treated rats. Histopathological lesions in thiamine-treated livers and kidneys were milder in comparison to lesions in untreated Pb-exposed anima ls. This indicates the prophylactic potential of thiamine for lead induced lipid peroxidation.