M. Muller et al., Effects of dopexamine and volume loading on hemodynamics and oxygenation parameters in patients undergoing pulmonary resection, ACT ANAE SC, 44(7), 2000, pp. 858-863
Citations number
31
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Background: Pulmonary resection may result in a reduction in arterial oxyge
n pressure as well as in cardiac output. Since cardiac index, oxygen delive
ry, and oxygen consumption are considered as important determinants of pati
ents' outcome, we evaluated the effects of dopexamine and volume loading on
cardiopulmonary variables in patients undergoing pulmonary resection
Methods: Forty adult patients undergoing pulmonary resection for lung or br
onchial tumors were included in an open placebo-controlled study. The patie
nts were selected according to a randomized sequence to group A (n=20) or g
roup B (n=20). Dopexamine (2 mu g . kg(-1) . min(-1)) was started when stea
dy state conditions were achieved after induction of anesthesia in group A.
Saline 0.9% was given as control (group B). Hemodynamic monitoring was per
formed using a pulmonary artery catheter.
Results: Dopexamine increased heart rate, cardiac output and oxygen deliver
y compared with control without increasing oxygen consumption during anesth
esia and surgery Furthermore, dopexamine was found not to alter the course
of PaO2/FiO2 values.
Conclusion: In patients undergoing pulmonary resection, dopexamine can be u
sed perioperatively to increase cardiac index without decreasing the PaO2/F
iO2 ratio.