The modified Fontan procedure has gained wide acceptance in the treatment o
f various congenital heart defects, Determination of risk factors for morta
lity remains an important issue for optimizing patient selection for the Fo
ntan procedure. Conflicting results have been reported about whether ventri
cular morphology is a risk factor in these patients. Survival free of Fonta
n takedown or cardiac transplantation was assessed in the first 500 patient
s undergoing the Fontan procedure at our institution. This survival was cor
related with ventricular morphology as evaluated by angiography, Both multi
variate and univariate analyses indicated ventricular morphology was predic
tive of early survival free of Fontan takedown or cardiac transplantation f
ollowing the procedure. However, there wets no statistical evidence for ven
tricular morphology being a risk factor for mortality in patients alive 6 m
onths after the procedure. Ventricular morphology is a risk factor for earl
y survival in patients undergoing a Fontan procedure, with left ventricular
morphology associated with a better early survival than right ventricular
morphology. (C) 2000 by Excerpta Medica, Inc.