Kd. Miller et al., Lactic acidosis and hepatic steatosis associated with use of stavudine: Report of four cases, ANN INT MED, 133(3), 2000, pp. 192-196
Citations number
20
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Background: An association between use of zidovudine and didanosine and a r
are but life-threatening syndrome of hepatic steatosis, lactic acidosis, an
d myopathy has been reported.
Objective: To describe the syndrome of hepatic steatosis, lactic acidosis,
and myopathy in four patients taking stavudine.
Design: Case series.
Setting: A community hospital in Washington, D.C., and National Institutes
of Health Clinical Center, Bethesda, Maryland.
Patients: Two men and two women with HIV-1 infection who were taking stavud
ine presented with lactic acidosis and elevated levels of aminotransferases
. All patients required intensive care.
Measurements: Levels of lactic acid, alanine aminotransferase, aspartate am
inotransferase, amylase, and lipase; computed tomography of the abdomen; li
ver biopsy (two patients); and muscle biopsy (two patients).
Results: Histologic findings consistent with mitochondrial injury confirmed
the diagnosis of hepatic or muscle abnormality.
Conclusion: Because hepatic steatosis may be life-threatening, physicians s
hould consider it as a possible cause of elevated hepatic aminotransferase
levels among patients taking stavudine.