FIXED LOW-DOSE COMBINATION OF AN ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR AND A CALCIUM-CHANNEL BLOCKER DRUG IN THE TREATMENT OF ESSENTIAL-HYPERTENSION

Aim To review the possibilities of combination treatment in hypertensi on with special emphasis on the combination of an angiotensin converti ng enzyme (ACE) inhibitor and a calcium channel blocker. Results An in creasing number of combination drugs has become available. Fixed combi nations, often low-dose, have proved suitable for the treatment of hyp ertension, even as first-line therapy. Conclusion A fixed combination of an ACE inhibitor and a calcium channel blocker, in particular the c ombination of trandolapril and verapamil, is a suitable alternative to existing treatment modalities.