In vitro reversion of amphotericin B resistance in Leishmania donovani by poloxamer 188

Authors
Espuelas, S Legrand, P Loiseau, PM Bories, C Barratt, C Irache, JM
Citation
S. Espuelas et al., In vitro reversion of amphotericin B resistance in Leishmania donovani by poloxamer 188, ANTIM AG CH, 44(8), 2000, pp. 2190-2192
Citations number
24
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
8
Year of publication
2000
Pages
2190 - 2192
Database
ISI
SICI code
0066-4804(200008)44:8<2190:IVROAB>2.0.ZU;2-S
Abstract
A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 1 88 was evaluated against an AmB Leishmania donovani-resistant line. A conca ve isobologram showed a synergistic effect of this association against prom astigotes. This result was confirmed with amastigotes since the 50% effecti ve concentration of the new formulation was 100 times less than that of the control AmB formulation.