S. Mcguire et al., Increased immunoreactivity of glutathione-S-transferase in the retina of Swiss Webster mice following inhalation of JP8+100 aerosol, ARCH TOXIC, 74(4-5), 2000, pp. 276-280
The current study was designed to determine whether exposure of mice to aer
osolized jet fuel (JP8 + 100) resulted in changes in the cellular distribut
ion or immunoreactivity of the enzyme glutathione-S-transferase (GST), a bi
omarker of toxicant exposure. Male mice were exposed to JP8 + 100 at 1000 m
g/m(3) 2500 mg/m(3) in aerosol for 1 h per day for 7 days and then sacrific
ed. The retinas were studied by immunohistochemical methods. The JP8 + 100
exposure caused a marked increase in the immunoreactivity of anti-GSTM anti
bodies with the radial glial cells of the retina, the Muller cells. These r
esults are consistent with the hypothesis that JP8 + 100 acts as a toxicant
to mouse retina by permitting the flux of materials across the blood-retin
a barrier. The findings are relevant to humans because recent studies indic
ate that Air Force personnel assigned to clean and maintain fuel pods may b
e exposed to concentrations of JP8 + 100 exceeding 1000 mg/m(3).