The facile production of N-methyl amino acids via oxazolidinones

Citation
L. Aurelio et al., The facile production of N-methyl amino acids via oxazolidinones, AUST J CHEM, 53(5), 2000, pp. 425-433
Citations number
41
Categorie Soggetti
Chemistry
Journal title
AUSTRALIAN JOURNAL OF CHEMISTRY
ISSN journal
00049425 → ACNP
Volume
53
Issue
5
Year of publication
2000
Pages
425 - 433
Database
ISI
SICI code
0004-9425(2000)53:5<425:TFPONA>2.0.ZU;2-6
Abstract
A range of oxazolidinones derived from N-carbamoyl alpha-amino acids were p repared by an efficient method as key intermediates in the synthesis of N-m ethyl amino acids and peptides. The method was readily applied to most alph a-amino acids except those with basic side chains. The oxazolidinones were converted by reductive cleavage into N-methyl alpha-amino acids.