Cytosensor techniques for examining signal transduction of neurohormones

This review describes the principles of microphysiometry and how they can b e applied, using the Cytosensor, to the investigation of the signal transdu ction mechanisms activated by both G-protein and non-a-protein coupled horm one and neuropeptide receptors. The use of the Cytosensor to study desensit isation and cross-talk is also discussed, as are the benefits and limitatio ns of this technique.