One-pot synthesis and biological evaluation of aspergillamides and analogues

Authors
Beck, B Hess, S Domling, A
Citation
B. Beck et al., One-pot synthesis and biological evaluation of aspergillamides and analogues, BIOORG MED, 10(15), 2000, pp. 1701-1705
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
15
Year of publication
2000
Pages
1701 - 1705
Database
ISI
SICI code
0960-894X(20000807)10:15<1701:OSABEO>2.0.ZU;2-8
Abstract
A one-pot total synthesis of aspergillamide and analogues by a solution pha se Ugi multi component reaction (MCR) is described. The reaction is easily performed in 96-well plates and offers a facile access to diverse aspergill amide analogue compound libraries. The antibiotic and cytotoxic activity of these compounds is measured. Several of them are more potent than the natu ral product. (C) 2000 Elsevier Science Ltd. All rights reserved.