Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors

Authors
Patel, M McHugh, RJ Cordova, BC Klabe, RM Erickson-Viitanen, S Trainor, GL Rodgers, JD
Citation
M. Patel et al., Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors, BIOORG MED, 10(15), 2000, pp. 1729-1731
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
15
Year of publication
2000
Pages
1729 - 1731
Database
ISI
SICI code
0960-894X(20000807)10:15<1729:SAEOQA>2.0.ZU;2-V
Abstract
A series of 3,3-disubstituted quinoxalinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The N-allyl (6b and 6f), N-cyclopro pylmethyl (6a, 6g, 6h, and 6k) and N-carboalkoxy (6m 6y) substituted compou nds displayed activity comparable or better than Efavirenz and GW420867X. ( C) 2000 Dupont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.