The relationship between lipid abnormalities and the pathogenesis of renal
disease is still unclear. Although most patients with primary hyperlipidemi
a do not develop renal function impairment, experimental and clinical data
indicate a possible damaging effect of a disturbed lipid metabolism on the
kidney. We report the case history of a patient with hyperlipidemia and mil
d nephropathy in which an accidentally removed kidney showed intrarenal art
eriosclerosis which occured before the development of other cardiovascular
risk factors, indicating that primary dyslipidemia induced nephroangioscler
osis.