Fluoxetine - A review of its use in anxiety disorders and mixed anxiety and depression

Sources: Medical literature published in any language since 1983 on fluoxet ine, identified using AdisBase (a proprietary database of Adis Internationa l Auckland, New Zealand) and Medline. Additional references were identified from the reference lists of published articles. Bibliographical informatio n, including contributory unpublished data, was also requested from the com pany developing the drug. Search strategy: Adis Base search terms were 'fluoxetine' or 'LY-110140 and ('generalised-anxiety-disorders' or 'obssessive-compulsive-disorders' or ' post-traumatic-stress-disorder' or 'panic-disorder' or 'agoraphobia' or 'so cial phobia' or 'comorbid depression'). Medline search terms were 'fluoxeti ne' and ('compulsive-personality-disorder' or 'stress-disorders-post-trauma tic' or 'panic-disorder' or 'agoraphobia' or 'generalised anxiety disorders ' or 'social phobia' or 'comorbid depression'). Searches were last updated 12 June 2000. Selection: Studies in patients with panic. obsessive-compulsive, post-traum atic stress or social anxiety disorder, or mixed anxiety with depression. w ho received fuoxetine. inclusion of studies was based mainly on the methods section of the trials. When available, large, well controlled trials with appropriate statistical methodology were preferred. Relevant pharmacodynami c and pharmacokinetic data are also included.