DESIGN, SYNTHESIS AND USE OF BINARY ENCODED SYNTHETIC CHEMICAL LIBRARIES

With the advent of combinatorial chemistry a new paradigm is evolving in the field of drug discovery. The approach is based on an integratio n of chemistry, high-throughput screening and automation engineering. The chemistry arm is usually based on solid-phase synthesis technology as the preferred approach to library construction. One of the most po werful of the solid-phase methods is encoded split synthesis, in which the reaction history experience by each polymeric bead is unambiguous ly recorded. This split-and-pool approach, employing chemically robust tags, was used to construct a 85 000-membered dihydrobenzopyran libra ry.