Squamous metaplasia of the stomach is a rare clinical entity that occurs du
ring healing of gastric ulcers or chronic inflammation. We have treated two
patients with this condition, which has only occasionally been observed en
doscopically. The first was a 60-year-old woman who initially presented wit
h multiple gastric ulcers. Two months after treatment, a white patch about
4 cm in diameter was found in the lesser curvature of the cardiac region of
stomach. The second patient was a 65-year-old woman, who also developed a
white patch in the same region. Two months later, a small ulcer and inflame
d mucosa were seen near the lesion. The white areas in both patients were s
tained with Lugol's iodine solution, and biopsy specimens confirmed squamou
s epithelium. The squamous metaplasia was observed as a white mucosal area
in the stomach, and the metaplastic area stained positively with Lugol's io
dine solution.