Molecular alterations in gastric cancer: the role of Helicobacter pylori

Helicobacter pylori has been classified as a human carcinogen contributing to the pathogenesis of gastric cancer. Extensive sero-epidemiological studi es and recently animal experiments have established a close link between H. pylori infection and the development of gastric cancer. However, the molec ular changes induced by H. pylori directly or the concomitant chronic infla mmation of the gastric mucosa, and the impact of these changes on the subse quent development of gastric cancer, remain largely unknown. This review wi ll highlight the present knowledge on the molecular pathogenesis of gastric cancer with an emphasis on molecular and genetic alterations which develop due to chronic infection of the gastric mucosa by H. pylori. Eur J Gastroe nterol Hepatol 12:795-798 (C) 2000 Lippincott Williams & Wilkins.