LIPIDS IN SERUM OF PATIENTS WITH MALIGNANT OVARIAN NEOPLASMS

Objective: In numerous papers, different associations of serum lipids and lipoproteins with neoplastic diseases were found. The aim of our w ork was to find out associations between levels of 11 serum lipids, li poproteins and ovarian cancer. Methods: 25 healthy women and 25 patien ts with ovarian cancer underwent examinations. Uni- and multivariate a nalysis of variance and discrimination analysis were used to analyze o ur results. Results: The analysis demonstrates that ovarian carcinoma is associated with a significant reduction of total cholesterol and it s esters in serum and in high density lipoprotein fractions compared t o controls. Conclusion: It could be shown that using multivariate anal ysis of variance it is possible to find the optimal set of serum lipid parameters, containing serum esterified cholesterol, serum total chol esterol and high density lipoproteins esterified cholesterol, to diffe rentiate healthy persons from patients affected by ovarian cancer. (C) 1997 International Federation of Gynecology and Obstetrics.