Fluvastatin combined with 17 beta-estradiol: Effect on the oxidation of human low density lipoprotein

The in vitro effect of a statin and an estrogen on oxidation of human LDL w as investigated for the first time, comparing the monosubstances fluvastati n and 17 beta-estradiol as well as the effect of the combination. Fluvastat in significantly delayed the onset of LDL oxidation (controls = 90 min) by 23 min at 1 mu M by 110 min and by 221 min at 5 and 10 mu M, respectively. 17 beta-estradiol significantly impeded the onset by 70 min at 1 mu M and b y more than 300 min at 5 and 10 mu M. The combination of 1 mu M 17 beta-est radiol with 1, 5 and 10 mu M fluvastatin showed an additive antioxidative e ffect. the onset was delayed by 100 min, by 167 min. and by more than 300 m in, respectively II can he concluded that treatment of postmenopausal women with fluvastatin and 17 beta-estradiol may have not only beneficial effect s on lipid disorders but may also elicit a di red potent anti-atherosclerot ic action on the vasculature.