Adsorption of Omeprazole on latex particles and characterization of the complex

Omeprazole is an antisecretory drug used against gastric ulcers. It quickly decomposes in an acid medium, however, therefore making it a matter of gre at interest to protect it in these conditions and determine the ideal adsor ption conditions for this drug on latex particles for formulation designs - oral suspensions - containing polymers with the aim of delivering differen t drugs in a sustained and controlled action. Time, pH, and concentration o f the active ingredient for which maximum adsorption occurs, were determine d. The findings suggest that adsorption is evidently greatest at an acid pH 4-5, that the adsorption of Omeprazole rises concomitantly with the increa se in latex particles, and the time is the least influential factor. (C) 20 00 Elsevier Science S.A. All rights reserved.